It has been over ten years since the Raccoon City incident, and the President of the United States has decided to reveal the truth behind what happened in the belief that it will curb the current resurgence of bioterrorist activity. At the President's side is his personal friend and Raccoon City survivor, Leon S. Kennedy, but when their area is subjected to a bioterrorist attack, Leon is forced to face a President transformed beyond recognition and must make his most difficult decision ever. At the same time, Bioterrorism Security Assessment Alliance member Chris Redfield arrives in China, which is under threat of a bioterrorist attack. With no country safe from these attacks and the subsequent epidemics, the population of the entire world is united in the common fear that there is no further hope.